Valsamaki P
General Hospital of Athens Alexandra, Greece
Title: Uterine leiomyomas in the differential diagnosis upon 99mTc-EDDA/HYNIC-TOC interpretation
Biography
Biography: Valsamaki P
Abstract
The diagnostic algorithm of neuroendocrine tumours encompasses somatostatin receptor scintigraphy as a useful non-invasive method which shows high sensitivity and specificity. This technique also indicates the option of targeted therapeutic “cold” or “hot” (radiolabeled) somatostatin analogue application. We present three cases of uterine leiomyomas with or without uterus dislocation, identified by 99mTc-EDDA/HYNIC-TOC (Tektrotyd) in women of different ages. Images obtained 75 min up to 240 min after injection of 740 MBq of 99mTc-labeled EDDA/HYNIC-TOC show areas of abnormally increased uptake in pelvis, with or without bladder compression. Our cases indicate that somatostatin receptors may be present in the uterus and in leiomyomas, irrespective of age. The findings were confirmed by other imaging modalities, such as US, CT and/or MRI. Uterine leiomyoma(s) somatostatin receptor expression proposes the potential utilization of somatostatin analogues in the non-invasive treatment armamentarium of these disease entities. Limited literature reports, compatible with our observations, highlight the significance of this finding in the differential diagnosis of respective positive studies.