Renata Markosyan
Yerevan State Medical University, Armenia
Title: A rare case of papillary carcinoma at children’s age
Biography
Biography: Renata Markosyan
Abstract
The issues of etiology, pathogenesis, diagnostics, treatment and prognosis of the patients with thyroid cancer have been in the focus of the fundamental and clinical researches for the last two decades.
The character of the tumor clinical “behavior” is due to the variety of the histological types of the thyroid gland cancer. The search of genetic anomalies, causing hereditary predisposition to the thyroid gland cancer development, is clinically demanded direction of fundamental medicine. Studies revealed that hereditary (germinal) mutations in RET prooncogen often play role in the thyroid gland medullar cancer etiology. V600E mutation in BRAF gene prevailed in most cases and prevails in papillary carcinomas, it is also revealed in anaplastic and slightly differentiated carcinomas, originated from papillary carcinoma.
It is obvious, that the problem is of utmost importance. This proves the necessity of not only further improvement of the existing diagnostic methods and their efficacy evaluation, but also the search of new noninvasive research methods, which are informative enough, as well as developing of optimal diagnostic algorithm to diagnose thyroid tumor earlier and rational surgical and curative tactics in patients with such pathology.
Patient’s early age, aggressive course of the disease, as well as papillary cancer incidence in the family, what indicates the possibility of hereditary genesis, makes the specificity of the presented case. All this urges the necessity to carry out molecular genetic studies to reveal mutations.